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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Acteoside, Temozolomide
Phytochemical Name Acteoside (PubChem CID: 5281800 )
Anticancer drug Name Temozolomide (PubChem CID: 5394 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 426
Ref_1
Pair Name Acteoside, Temozolomide
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Apoptosis and autophagy
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Cleavage CASP3 hsa836
Up-regulation Phosphorylation MAPK1 hsa5594
Up-regulation Phosphorylation MAPK14 hsa1432
Up-regulation Phosphorylation MAPK8 hsa5599
Up-regulation Expression RAB7A hsa7879
Up-regulation Expression SQSTM1 hsa8878
Up-regulation Phosphorylation TP53 hsa7157
In Vitro Model C6 Rat malignant glioma Rattus norvegicus (Rat) CVCL_0194
Result It was also determined that TMZ + acteoside induced apoptosis and autophagy through the mitogen‑activated protein kinase signaling pathway. These findings suggest that acteoside has beneficial effects on TMZ‑based glioblastoma therapy.
03. Reference
No. Title Href
1 Synergistic anticancer effect of acteoside and temozolomide-based glioblastoma chemotherapy. Int J Mol Med. 2019 Mar;43(3):1478-1486. doi: 10.3892/ijmm.2019.4061. Click
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